A defined barley seed extract with human-like growth factor activity, developed and produced exclusively for BIOEFFECT

DERMOkine is a defined barley seed extract, exclusively developed and produced for ORF Genetics’ skin care application, BIOEFFECT. The product contains high-quality, endotoxin-free growth factors, produced in the endosperm tissue of the barley plant (Hordeum vulgare).

The growth factors in DERMOkine are bioengineered, plant-based replicas of EGF (Epidermal Growth Factor), a naturally occurring human protein.


ORF Genetics founded BIOEFFECT following its scientists’ discovery of the method to produce the EGF replica. BIOEFFECT has since become a global success and its growing line of products is sold worldwide.

BIOEFFECT aims to restore and maintain skin’s natural youthfulness and vitality through effective biotechnological skincare products, containing healthy, pure ingredients.

When developing an effective skincare product, it is key to understand what affects skin cells’ performance and what components are vital to their healthy function. Growth factors play an important role in the regulation of cell growth and maintenance. EGF is one of the most important growth factors in the skin, as it stimulates the production of collagen and elastin, helping to maintain a healthy, dense, and youthful skin. With age, production of growth factors decreases, leading to slower cell regeneration and repair, and eventually affecting skin appearance.

Topical applications of growth factors in an appropriate formulation therefore have a significant potential for reversing aging effects on the skin, as is supported by a number of clinical studies.

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1Our Standard

Purity over excess

We use only the essentials — as few as 7 simple, natural ingredients that are effective and easy to understand.

2Our Belief

Truth in aging

We aim to empower the world to choose how they age.

3Our Promise

Visible results

We don’t do the same thing better; we do the radically unprecedented, and we ensure absolute, visible results, supported by double-blinded, placebo-controlled efficacy studies.

4Our Foundation

Clean barley EGF

Our plant-based growth factors are a safe alternative to the EGF sourced from humans.

To restore and maintain the skin's natural youthfulness and vitality through healthy, pure ingredients and truly effective advancements in skincare.