ISOkine® PREMIUM - Bridging Research and Clinical Development.

Human and mouse growth factors and other cytokines for stem cell research, regenerative medicine, and organoid production.

ISOkine® Animal-Free, PREMIUM growth factors & cytokines are animal- and serum-free, void of antibiotics with low pyrogenic and pro-inflammatory activity, no bacterial endotoxins, viruses, and prions.

With the extensive progress in the field of stem cell research and cell-based therapy applications, the market is demanding Animal-Free, Endotoxin-free, pure recombinant proteins of high quality. Our ISOkine® Animal-Free PREMIUM growth factors & cytokines support researchers meet that demand as they are specifically produced for stem cell research. ISOkine® Animal-Free PREMIUM products are used in laboratories by scientists to stimulate and control destiny of stem cells. They are applied in both pre-clinical research and large-scale cell cultures, as growth factors play a critical role in regenerative medicine and cell therapy.

Our ISOkine® Animal-Free PREMIUM GF&C biological activity is at least comparable or higher than other commercially available growth factors and cytokines, reflecting the proper and efficient eukaryotic folding and glycosylation pattern of proteins produced in plant cells. Each batch is tested for biological activity and bioactivity data is provided with each batch.

ISOkine® was ORF Genetics' first product line to reach the market in 2007. We have been producing ISOkine® Animal-Free PREMIUM GF&C for over 18 years for a global R&D and Biotech audience. Renewable geothermal energy is used in their production, leaving a low carbon footprint and making them the most environmental-friendly recombinant proteins in the research and clinical market.

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You can also purchase your ISOkine® ANIMAL-FREE PREMIUM GF&C directly from our preferred distributionpartners

  • FranceFrance
  • GermanyGermany
  • NL/BE/LUXNL/BE/LUX
  • IT/FR/NO/SE/FI/DK/PTIT/FR/NO/SE/FI/DK/PT
  • UKUK
  • SpainSpain
  • CzechiaCzechia
  • PolandPoland
  • ItalyItaly
  • CanadaCanada
  • USAUSA
  • USAUSA
  • USAUSA
  • sSA - AfricasSA - Africa
  • South KoreaSouth Korea
  • Japan - USAJapan - USA
  • ChinaChina
  • TaiwanTaiwan

"The plant-origin of our ISOkine® growth factors and the endotoxin-free aspect have earned us some very loyal customers within the stem cell research community during the last ten years, that appreciate our focus on high quality and consistency in performance"

Dr. Björn Örvar CSO, ORF Genetics

About the product

  • Animal Origin-Free, Animal Component-Free (ACF), Endotoxin-free, PREMIUM growth factors and cytokines produced in the endosperm of barley seeds. They are animal and serum-free, void of antibiotics, pyrogenic and pro-inflammatory-free, void of bacteria, viruses, and prions, and are eukaryotic folded and glycosylated. Their production is environmentally friendly and CO2 neutral, as renewable, geothermal energy is used in their production. Furthermore, the biological activity typically is comparable or better than of other commercially available growth factors and cytokines. Each batch of ISOkine® PREMIUM growth factors and cytokines is tested for biological activity by independent third-party companies and all bioactivity information is provided in a data sheet for each batch of every product.

  • As our recombinant growth factors and cytokines are produced in barley seeds, they do not have animal origin nor come in contact with any animal derived substances throughout their production cycle and are fully Animal Origin-Free, Animal Component-Free (ACF).

  • Our ISOkine® PREMIUM growth factors and cytokines are produced in barley and purified in our laboratories where we only process barley derived proteins. Therefore, we can exclude any contact of our products with bacteria, virus, or prion derived contaminants.

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Why Endotoxin-free Growth Factors

Endotoxin-free growth factors increase precision and reproducibility of stem cell cultures

Increased reproducibility leads to more consistency in stem cell experiments

Increased reproducibility leads to smoother transfer of an already established stem cell culture protocol from pre-clinical research to clinical trials

Barley Means Purity in Molecular Farming

We bypass entirely the use of bacteria

We bypass entirely the use of animal or human cells

Produced in plants grown in a geothermal high-tech greenhouse with a negative CO2 footprint