ISOkine® PREMIUM - Bridging Research and Clinical Development.
Human and mouse growth factors and other cytokines for stem cell research, regenerative medicine, and organoid production.
ISOkine® Animal-Free, PREMIUM growth factors & cytokines are animal- and serum-free, void of antibiotics with low pyrogenic and pro-inflammatory activity, no bacterial endotoxins, viruses, and prions.
With the extensive progress in the field of stem cell research and cell-based therapy applications, the market is demanding Animal-Free, Endotoxin-free, pure recombinant proteins of high quality. Our ISOkine® Animal-Free PREMIUM growth factors & cytokines support researchers meet that demand as they are specifically produced for stem cell research. ISOkine® Animal-Free PREMIUM products are used in laboratories by scientists to stimulate and control destiny of stem cells. They are applied in both pre-clinical research and large-scale cell cultures, as growth factors play a critical role in regenerative medicine and cell therapy.
Our ISOkine® Animal-Free PREMIUM GF&C biological activity is at least comparable or higher than other commercially available growth factors and cytokines, reflecting the proper and efficient eukaryotic folding and glycosylation pattern of proteins produced in plant cells. Each batch is tested for biological activity and bioactivity data is provided with each batch.
ISOkine® was ORF Genetics' first product line to reach the market in 2007. We have been producing ISOkine® Animal-Free PREMIUM GF&C for over 18 years for a global R&D and Biotech audience. Renewable geothermal energy is used in their production, leaving a low carbon footprint and making them the most environmental-friendly recombinant proteins in the research and clinical market.
Our Growth Factors and other Cytokines
EGF (Epidermal Growth Factor)
Human - IK0100 10μg up to 5mg
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FGF-2 (bFGF, FGF basic)
Human - IK0200 10μg up to 5mg
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Flt-3 ligand
Human - IK1700 10μg up to 5mg
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G-CSF
Human - IK1800 10μg up to 5mg
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GDNF
Human - IK0900 10μg up to 5mg
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IFN-gamma
Human - IK2000 10μg up to 5mg
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IGF-1, LR3
Human - IK0300 10μg up to 5mg
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IL-2 (Interleukin 2)
Human - IK2100 10μg up to 5mg
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IL-4 (Interleukin 4)
Human - IK2300 10μg up to 5mg
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KGF (FGF 7, HBGF 7)
Human - IK0600 10ug up to 5mg
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LIF (Leukemia inhibitory factor)
Human - IK0700 10μg up to 5mg
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LIF mouse (ESC–qualified)
Mouse - IK0701 10μg up to 5mg
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M-CSF (CSF-1)
Human - IK2400 10μg up to 5mg
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SCF (Stem Cell Factor)
Human - IK2500 10μg up to 5mg
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SCF mouse (Stem Cell Factor)
Mouse - IK2501 10μg up to 5mg
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TNF-alpha
Human - IK2600 10μg up to 5mg
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VEGF 165
Human - IK0500 10μg up to 5mg
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PDGF-BB - now available!
Human IK1000 - 10μg up to 5mg
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IL-15 - New for 2026
Human IK2900 - NEW
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IL-21 - New for 2026
Human IK3100 - NEW
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IL-6 - New for 2026
Human IK0400 - NEW
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Noggin - New for 2026
Human IK0800 - NEW
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Dr. Björn Örvar CSO, ORF Genetics"The plant-origin of our ISOkine® growth factors and the endotoxin-free aspect have earned us some very loyal customers within the stem cell research community during the last ten years, that appreciate our focus on high quality and consistency in performance"
About the product
Animal Origin-Free, Animal Component-Free (ACF), Endotoxin-free, PREMIUM growth factors and cytokines produced in the endosperm of barley seeds. They are animal and serum-free, void of antibiotics, pyrogenic and pro-inflammatory-free, void of bacteria, viruses, and prions, and are eukaryotic folded and glycosylated. Their production is environmentally friendly and CO2 neutral, as renewable, geothermal energy is used in their production. Furthermore, the biological activity typically is comparable or better than of other commercially available growth factors and cytokines. Each batch of ISOkine® PREMIUM growth factors and cytokines is tested for biological activity by independent third-party companies and all bioactivity information is provided in a data sheet for each batch of every product.
As our recombinant growth factors and cytokines are produced in barley seeds, they do not have animal origin nor come in contact with any animal derived substances throughout their production cycle and are fully Animal Origin-Free, Animal Component-Free (ACF).
Our ISOkine® PREMIUM growth factors and cytokines are produced in barley and purified in our laboratories where we only process barley derived proteins. Therefore, we can exclude any contact of our products with bacteria, virus, or prion derived contaminants.

Why Endotoxin-free Growth Factors
Endotoxin-free growth factors increase precision and reproducibility of stem cell cultures
Increased reproducibility leads to more consistency in stem cell experiments
Increased reproducibility leads to smoother transfer of an already established stem cell culture protocol from pre-clinical research to clinical trials
Nice to know
Other useful information relating to our ISOkine growth factors.















