Animal-free growth factors & cytokines
Three product lines. One quality system.
ISOkine® for stem cell research, MESOkine® for cultivated meat and seafood, DERMOkine for cosmetic ingredients -- all animal-free, endotoxin-free, and ISO 9001 certified.
ISO 9001 certified. Worldwide distribution.
Trusted worldwide
Trusted by teams advancing the future of food and science
ISO 9001:2015 certified · 25 years of molecular farming · companies worldwide in cultivated meat and research
What to look for
Not all growth factors are equal
Batch variability, animal-derived contamination risk, and cost at scale are the three variables that define whether a growth-factor supplier can support your work.
Batch variability stalls research
Inconsistent purity or bioactivity forces re-validation and risks your results. Every batch must perform like the last.
Animal-derived inputs add risk
Serum and animal-component sources introduce contamination, endotoxin risk, and supply uncertainty. An endotoxin-free, animal-free host removes that layer of biorisk.
Cost and volume don't scale together
Conventional growth factors are expensive and hard to scale from pre-clinical to production. A molecular-farming platform changes the cost curve.
Find your product line
Pick your application
Each product line is matched to a distinct application. All share the same animal-free, endotoxin-free quality system and are backed by 25 years of molecular farming.
ISOkine® Premium -- human and mouse growth factors and cytokines, animal-free and endotoxin-free, for stem cell research, organoid production, regenerative medicine, and cell therapy. Produced in bioengineered barley for consistent, native eukaryotic folding.
- >95-98% purity, endotoxin-free
- Bioactivity tested every batch -- CoA provided
- Human and mouse catalog: EGF, FGF basic, LIF, SCF, Noggin, IL-6, GDNF, VEGF, PDGF-BB, and more
- ISO 9001:2015 certified
MESOkine® -- species-specific animal growth factors for cultivated meat and related industries. Recombinant bovine, porcine, and avian proteins in a defined barley seed extract, bioassay-verified against commercial references. Designed for cost reduction and scale.
- Bioactivity confirmed in independent commercial bioassays
- Barley seed proteins serve as natural stabilisers -- prolongs shelf life
- Bovine, porcine, avian catalog: FGFb, IGF-1 LR3, PDGF-BB, Transferrin, VEGF, and more
- Built for production-scale cost curves
DERMOkine -- human growth factors in a defined barley seed extract, developed for skincare and haircare formulation. A portfolio of human growth factor and biopeptide replicas for cosmetic-grade ingredient applications.
- Human-like growth factors and biopeptides (DK catalog)
- Endotoxin-free, plant-produced
- Proven in award-winning premium skincare (BIOEFFECT customer reference)
- ISO 9001 certified
The quality system
Why animal-free in barley produces cleaner proteins
The Orfeus barley-seed expression platform is the only reason ORF's three product lines are all endotoxin-free, animal-free, and consistently high-bioactivity. It is the shared quality foundation.
No endotoxins, by choice of host
Bacterial expression systems produce lipopolysaccharide endotoxins as a natural by-product. ORF's barley host produces no endotoxins -- the result is an expression platform where endotoxin-free is the default, not a downstream purification target. Every lot is confirmed below 0.01 EU/µg.
Bioactivity data ships with every order
Each lot is tested in a cell-based proliferation assay before release. MESOkine bioactivity is confirmed by independent research organisations against a commercial reference (>95% purity). ISOkine bioactivity is at least comparable to, or higher than, commercially available mammalian-expressed references -- reflecting native eukaryotic folding and glycosylation from the plant host.
What buyers ask before requesting a quote
Answers to the top questions we receive from scientists and process-development teams evaluating our product lines.
Get started
Three product lines. One trusted supplier.
Talk to our scientists about which product line fits your application, or request a quote. ISO 9001 certified, worldwide distribution.
Quote-based, no account needed. Datasheets available on request.