Animal-free human & mouse growth factors
Consistent growth factors for your cell culture
ISOkine® Premium growth factors and cytokines are animal-free, endotoxin-free, and batch-tested for bioactivity — so your stem cell and organoid work is reproducible from first vial to scale.
ISO 9001 certified · 18 years of ISOkine production
Purpose-built for sensitive cell culture
ISOkine® Premium growth factors and cytokines are produced in bioengineered barley grain — an animal-free, endotoxin-free host. That means no animal-derived contamination, no batch-to-batch surprises from serum variability, and no compromises on purity. Every lot is tested for biological activity against a commercial reference before it ships.
Used by stem cell researchers, organoid labs, and cell therapy teams to maintain and expand cultures from early-stage research to large-scale pre-clinical work.
Growth factor variability stops experiments before they start
The cell-culture challenge
When bioactivity or purity fluctuates between lots, protocols have to be re-validated and experiments cannot be compared across runs.
Serum and mammalian cell-expressed proteins introduce endotoxin and animal-origin adventitious agents that sensitive stem cell cultures cannot tolerate.
Conventional growth factors priced for small-batch research become a budget constraint when expanding to pre-clinical or large-scale work.
Endotoxin-free, batch-consistent, plant-produced
How ISOkine® works
Endotoxin-free by design.
Produced in barley grain — a plant host — so there is no animal-derived contamination pathway and endotoxin levels are below 0.01 EU/µg by default. Cell cultures stay clean without additional endotoxin-removal steps, and protocols transfer more smoothly from research to pre-clinical work.
Every batch is bioactivity-tested.
Each lot of ISOkine® Premium is assayed for biological activity against a commercial reference source before it ships. You know the bioactivity before it reaches your lab — no wasted experiments from an underperforming lot.
Scalable economics.
Molecular farming in barley yields plant-cell concentrations that make volume pricing viable — from 10 µg trial quantities to gram-scale bulk orders. Growth factors stop being the cost constraint on your program.
The right proteins for your work
Choose by application
Stem cell & regenerative research
Human and mouse ESC, iPSC, and progenitor cell culture. ISOkine® Premium provides the endotoxin-free, animal-free factors used to maintain pluripotency, direct differentiation, and expand cell populations — without the batch variability that complicates protocol transfer.
- EGF (IK0100), FGF-2 (IK0200), LIF human (IK0700)
- LIF mouse (IK0701), SCF (IK2500), IGF-1 LR3 (IK0300)
Organoid & 3D culture
Intestinal, brain, liver, and lung organoids require a precise cytokine environment. ISOkine® factors — KGF, Noggin, EGF, VEGF — are endotoxin-free and pyrogen-free, reducing confounding inflammatory signals in sensitive 3D systems.
- EGF (IK0100), KGF / FGF-7 (IK0600)
- VEGF 165 (IK0500), Noggin (IK0800, inquire)
Cell & gene therapy
T-cell expansion, NK cell culture, and hematopoietic stem-cell protocols for cell therapy workflows. ISOkine® Premium interleukins and cytokines are animal-free and documented with Certificate of Origin — meeting the traceability requirements of pre-clinical development.
- IL-2 (IK2100), IL-4 (IK2300), IL-15 (IK2900)
- Flt-3 ligand (IK1700), G-CSF (IK1800), SCF (IK2500), PDGF-BB (IK1000)
ORF Genetics makes growth factors for more than research
Other product lines
MESOkine®
Species-specific growth factors (bovine, porcine, avian) for cultivated meat and seafood production. The same animal-free, endotoxin-free quality, engineered for large-scale cell culture of food animals.
Learn about MESOkine®
DERMOkine
Barley-seed extract with growth-factor activity for cosmetic and personal-care formulation. Proven in the award-winning BioEffect skincare line.
Learn about DERMOkine
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Ready to run cleaner, more reproducible experiments?
Talk to our scientists about your protocol and growth factor requirements, or request a quote. Worldwide distribution, ISO 9001 certified.
Worldwide distribution. Datasheets available for every product.