Cell & gene therapy
Animal-free cytokines for cell and gene therapy
ISOkine® interleukins and growth factors for T-cell expansion, CAR-T and cell-therapy workflows. Endotoxin-free, animal-free, and documented for pre-clinical development.
ISO 9001 certified, 25 years of molecular farming
Trusted by research teams worldwide
The cell-therapy challenge
Reagent variability and biorisk slow clinical translation
T-cell and NK-cell expansion is sensitive to cytokine potency. When bioactivity shifts between lots, you re-validate and repeat runs, and every delay pushes back your development timeline.
Bacterially expressed and animal-derived cytokines carry endotoxin and adventitious-agent risk that complicates the path from research to clinical-grade workflows.
Moving toward the clinic demands traceable, defined-condition reagents. Missing certificates and undefined components create qualification overhead.
Why ISOkine for cell therapy
Defined, documented cytokines for the road to the clinic
Tell us your application and we'll recommend the right factors.
Batch-consistent bioactivity
Each ISOkine® lot is tested in a cell-based assay and ships with a Certificate of Analysis. Consistent potency means fewer re-validations across your expansion protocols.
Endotoxin-free, low pyrogenic activity
Produced in barley rather than bacteria or animal cells, ISOkine® proteins come in at <0.01 EU/µg with low pyrogenic and pro-inflammatory activity, protecting sensitive immune-cell cultures.
Animal-free and documented for development
Animal- and serum-free, void of antibiotics, and shipped with a Certificate of Origin, ISOkine® cytokines fit defined-condition protocols for pre-clinical and early clinical development.
ISOkine® Premium
The cytokines cell and gene therapy workflows depend on
Interleukins for T-cell and NK-cell expansion
IL-2, IL-15, and IL-21 support T-cell and NK-cell expansion for CAR-T and adoptive cell-therapy workflows. Animal-free, endotoxin-free, and lot-tested for consistent potency.
See the ISOkine® range
Factors for hematopoietic and immune-cell culture
SCF, Flt-3 ligand, and G-CSF support hematopoiesis, dendritic-cell and neutrophil expansion, and stem-cell maintenance for immune-cell workflows.
Documentation for every lot
Datasheets, Certificates of Analysis, Safety Data Sheets, and Certificates of Origin are available for every ISOkine® factor. ISO 9001:2015 certified, on the road to GMP.
Explore the technologyFrom workflow to supply, in three steps
Getting started
Match cytokines to your workflow
Tell us your cell type and expansion protocol. Browse the ISOkine® catalog or talk to a scientist to identify the right interleukins and factors.
Request a quote or sample
Quote-based ordering, no account needed. Datasheets, SDS, CoA, and CoO documents are available for every factor.
Scale with documented consistency
The same lot-tested quality holds from research through pre-clinical work, so your process does not change as you scale.
Questions from cell and gene therapy teams
Answers to the questions cell and gene therapy teams ask most about ISOkine® cytokines.
ISOkine® proteins are animal- and serum-free, endotoxin-free (<0.01 EU/µg), with low pyrogenic and pro-inflammatory activity, and ship with a Certificate of Origin. That makes them suitable for defined-condition, pre-clinical and early clinical development workflows. ORF Genetics is ISO 9001:2015 certified and on the road to GMP.
IL-2, IL-15, and IL-21 are the primary interleukins for T-cell and NK-cell expansion, supported by SCF, Flt-3 ligand, and G-CSF for hematopoietic and immune-cell culture. All are available animal-free and endotoxin-free.
Every lot ships with a Certificate of Analysis, a Safety Data Sheet, a product datasheet, and a Certificate of Origin. Bioactivity data is included with every batch.
Get started
Build your cell-therapy process on documented cytokines
Talk to our scientists about your workflow or request a quote. ISO 9001 certified, worldwide distribution, datasheets available on request.
Quote-based ordering. Datasheets and CoA available on request. Worldwide distribution.